28 Apr 2016 Blackmores Institute Review finds nutritional supplements can increase the effectiveness of antidepressants 28 Apr 2016 Share Share on LinkedIn Share on Facebook Share on Twitter Share on Google+ Share on Pinterest News A recent international evidence review shows that certain nutritional supplements can increase the effectiveness of antidepressants for people with clinical depression. Omega 3 fish oils, S-adenosylmethionine (SAMe), methylfolate (a bioactive form of folate) and vitamin D, were all found to boost the effects of antidepressant medications. × To continue reading this article, please Log In or Sign Up for access.