09 Mar 2026 Blackmores Optimising magnesium prescribing 09 Mar 2026 Share Share on LinkedIn Share on Facebook Share on Twitter Share on Google+ Share on Pinterest News Key highlights Magnesium is involved in more than 600 enzymatic reactions essential for energy, cardiometabolic, neuromuscular, and bone health. Suboptimal intake is common, yet deficiency is often under-recognised due to nonspecific symptoms and limitations in assessment. Absorption and bioavailability vary considerably between supplemental forms. Clinical outcomes may be influenced not only by dose, but also by the ligand to which magnesium is bound. Magnesium is a foundational mineral central to human physiology.1 As the fourth most abundant mineral in the body and the second most prevalent intracellular cation after potassium, it participates in more than 600 enzymatic reactions supporting cardiometabolic, neuromuscular, and skeletal function.1 Approximately half of the total body magnesium resides in bone, with most of the remainder in muscle and soft tissues, and less than one per cent circulating in serum.2 × To continue reading this article, please Log In or Sign Up for access.