Animal study. ALA was shown to decrease significantly the in vitro formation of VA-CoA in a concentration-dependent manner

In vitro and/or animal evidence with unclear implications, however, it cannot exclude the possibility of occurring in humans

Intervention by a healthcare professional may be required

Anticonvulsants (valproate)

Anticoagulants and antiplatelet agents

Clinical evaluation by a healthcare professional is recommended to assess the degree of intervention required

Clinical trials suggest Alpha-lipoic acid (ALA) may affect glucose-lowering effect of these medications

Evidence suggests this interaction might occur in some patients