Blackmores Institute

Researchers found that individuals with &lt;30 nmol/L of serum 25(OH)D have approximately 183 percent higher diabetes prevalence compared to those with ≥75 nmol/L 25(OH)D. This translates into 70 percent increased risk of having diabetes in those with &lt;30 nmol/L serum 25(OH)D compared to those with ≥75 nmol/L serum 25(OH)D.
 
 In the cross-sectional study using data for circulating 25(OH)D concentrations from over 8000 participants in the National Health and Nutrition Examination Surveys from 2001- 2006 (&gt;19 years of age), the researchers found that 25(OH)D concentrations ≥75 nmol/L compared to those with &lt;30 nmol/L had improved cardiometabolic markers.
 
 “We found that serum 25(OH)D concentrations were significantly related to all individual markers of metabolic syndrome (MetS) and diabetes. The likelihood of having MetS and diabetes is linearly, inversely related to the serum 25(OH)D concentrations. The farther the below ≥75 nmol/L serum 25(OH)D, the greater the risk of having cardiometabolic diseases,” the researchers said.
 
 “Along these lines, the risk of having diabetes in the lower clinical cutoff serum 25(OH)D concentrations (&lt;75 nmol/L) is similar (overlapping 95% CI). This also suggests that serum 25(OH)D needed to be at or above 75 nmol/L in order to have a beneficial impact on the risk for diabetes.”
 
 These results are in agreement with previous studies according to the authors although they recommend randomised controlled trials to determine the intake level of vitamin D that reduces the risk of cardiometabolic diseases.
 
 “We also found individuals with &lt;30 nmol/L of serum 25(OH)D have approximately 183 percent higher diabetes prevalence compared to those with ≥75 nmol/L 25(OH)D. This translates into 70 percent increased risk of having diabetes in those with &lt;30 nmol/L serum 25(OH)D compared to those with ≥75 nmol/L serum 25(OH)D,” the authors said.
 
 The study also reported the individuals with ≥75 nmol/L 25(OH)D had approximately 5.9 percent higher VO2 max (a marker of cardiorespiratory fitness) compared to those with &lt;30 nmol/L suggesting a possible association between Vitamin D and VO2max relates to the protective effect of vitamin D on lung function.
 
 “Because this study was based on a nationally representative sample, these results are generalizable to the population at large described in this study, however, due to the cross-sectional nature of this study, results should not be viewed in terms of cause and effect relationships.
 
 “Our findings support the evidence that serum 25(OH)D concentrations ≥75 nmol/L are associated with improved metabolic pathologies related to inflammation, insulin resistance, MetS, and diabetes. Given the role of vitamin D in various metabolic functions and increased prevalence of hypovitaminosis D in the general population, more controlled studies are needed to determine whether serum 25(OH)D concentrations ≥75 nmol/L can be protective against cardiometabolic diseases,” the researchers concluded.
 
 Source:
 Nutrients. 2020. DOI: <a href="https://doi.org/10.3390/nu12030730">10.3390/nu12030730</a>

A US study has found that increased vitamin D levels are associated with improvements in cardiometabolic biomarkers, decreased prevalence of metabolic syndrome and diabetes, and increased maximal oxygen uptake in adults.

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